publication date: Friday, December 29, 2006 (part of Round XXIX)
clue: The human anatomy is not alien to this star behind two "Isibels."
explanation: Heigl played Isabel Evans on Roswell ("alien") and Isobel Stevens on Grey's Anatomy ("human anatomy"). more…
solved by: Russ Wilhelm, Steve West, Justin Woods, Matthew Preston, Denise Sawicki, Joanna Woods, Erik Bates, Mike Rothstein, Steve Dunn, Amy Austin, Mike Eberhart, David Mitzman, Elliot Farney, Jerry Mathis, Tony Peters, Scott Horowitz, Megan Baxter, Chris McKinnon, Michael Paul Cote, Todd Brotsch, Christine Marie Doiron, Adrianne Rodgers, Kerry Odell, Josh Paddison, Joy Dunn, and Chris Venit